mTORC 1 / 2 and rapamycin in female Han : SPRD rats with polycystic 1 kidney disease ( PKD )
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چکیده
mTORC1/2 and rapamycin in female Han:SPRD rats with polycystic 1 kidney disease (PKD). 2 3 Franck Belibi*, Kameswaran Ravichandran*, Iram Zafar*, Zhibin He and Charles L. 4 Edelstein. 5 6 Division of Renal Diseases and Hypertension, Univ. of Colorado at Denver and the 7 Health Sciences Center, Aurora, Colorado, USA 8 9 *Authors contributed equally to the study 10 11 12 Correspondence to Charles L. Edelstein, Division of Renal Diseases and Hypertension, 13 Univ. of Colorado at Denver and the Health Sciences Center, Box C281, 12700 East 14 19 th Ave, Aurora, CO 80262, USA. 15 Phone (303) 724-4810 FAX (303) 724-4868 16 e-mail: [email protected] 17 18 Running title: Rapamycin in female PKD rats. 19 20 21 Articles in PresS. Am J Physiol Renal Physiol (October 13, 2010). doi:10.1152/ajprenal.00129.2010
منابع مشابه
mTORC1/2 and rapamycin in female Han:SPRD rats with polycystic kidney disease.
Rapamycin slows disease progression in the male Han:SPRD (Cy/+) rat with polycystic kidney disease (PKD). The aim of this study was to determine the effect of rapamycin on PKD and the relative contributions of the proproliferative mammalian target of rapamycin complexes 1 and 2 (mTORC1 and mTORC2) in female Cy/+ rats. Female Cy/+ rats were treated with rapamycin from 4 to 12 wk of age. In vehic...
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